PRB4

Across TCGA patient cohorts, PRB4 mutation is significantly associated with the RNA expression of many other genes, with 656 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRB4-associated genes across cancer lineages are RNA5SP422, RNA5SP416, and RNA5SP419. Each is linked with PRB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRB4-to-partner and partner-to-PRB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP422 grouped by PRB4-low versus PRB4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB4→partner) and Y-score (partner→PRB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP422 →	+0.449	+8.055	<.001	.007	3	2
BRCA	RNA5SP416 →	+1.006	+8.471	<.001	.005	3	2
BRCA	RNA5SP419 →	+0.898	+7.731	<.001	.009	3	2
UCEC	INPP5F →	+0.509	+3.362	.005	.005	3	2
LUSC	POTED →	+0.045	+4.393	.004	.008	3	2
LUSC	MIRLET7F1 →	+0.523	+3.937	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 656 associations by consensus.

RNA5SP422 by PRB4 expression — BRCA

Explore this box plot interactively →