PRB4

Across TCGA patient cohorts, PRB4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRB4-associated genes across cancer lineages are FOXO3a_pS318_S321, eIF4E, and p38-MAPK_pT180_Y182. Each is linked with PRB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRB4-to-partner and partner-to-PRB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PRB4-low versus PRB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB4→partner) and Y-score (partner→PRB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.162	-2.312	.007	.034	3	2
UCEC	eIF4E →	+0.224	+3.013	.027	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.638	-2.446	.003	.020	3	1
UCEC	p62 Lck ligand →	+0.412	+3.179	.008	.010	3	1
UCEC	PCNA →	+0.296	+2.999	.004	.035	3	1
UCEC	PKC-delta_pS664 →	-0.135	-3.312	.019	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FOXO3a_pS318_S321 by PRB4 expression — UCEC

Explore this box plot interactively →