PRB4

Across TCGA cell cohorts, PRB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 672 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRB4-associated GO terms across cancer lineages are Nuclear-transcribed mRNA catabolic process, Neuropeptide signaling pathway, and Transcription elongation-coupled chromatin remodeling. Each is linked with PRB4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRB4-to-partner and partner-to-PRB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear-transcribed mRNA catabolic process grouped by PRB4-low versus PRB4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB4→partner) and Y-score (partner→PRB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Nuclear-transcribed mRNA catabolic process →	+0.039	+0.013	<.001	.003	3	5
SKIN	Neuropeptide signaling pathway →	-0.075	-0.011	<.001	.006	3	4
BLOOD_Myeloma	Transcription elongation-coupled chromatin remodeling →	+0.110	+0.042	<.001	.002	3	4
BLOOD_Lymphoma	Regulation of phospholipid translocation →	-0.135	-0.024	.002	.004	3	4
BLOOD_Lymphoma	Positive regulation of phospholipid translocation →	-0.135	-0.024	.002	.004	3	4
BLOOD_Lymphoma	Transcription elongation by RNA polymerase II →	+0.069	+0.014	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

Nuclear-transcribed mRNA catabolic process by PRB4 expression — BLOOD_Leukemia

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