PRB2

Across TCGA patient cohorts, PRB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,724 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible PRB2-associated GO terms across cancer lineages are Negative regulation of cytoskeleton organization, Cellular response to acid chemical, and mRNA 3'-end processing. Each is linked with PRB2 in more than 10 cancer types. Because this analysis shows association rather than direction, both PRB2-to-partner and partner-to-PRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytoskeleton organization grouped by PRB2-low versus PRB2-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB2→partner) and Y-score (partner→PRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Negative regulation of cytoskeleton organization →	+0.024	+0.067	<.001	<.001	3	10
TGCT	Cellular response to acid chemical →	+0.028	+0.063	<.001	<.001	3	10
OV	mRNA 3'-end processing →	+0.037	+0.407	<.001	<.001	3	10
TGCT	Regulation of protein-containing complex disassembly →	+0.027	+0.080	<.001	<.001	2	11
LAML	Negative regulation of stem cell differentiation →	+0.066	+0.424	<.001	<.001	3	9
TGCT	Obsolete selective autophagy →	+0.038	+0.091	<.001	<.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,724 associations by consensus.

Negative regulation of cytoskeleton organization by PRB2 expression — TGCT

Explore this box plot interactively →