PRB2

Across TCGA patient cohorts, PRB2 protein abundance is significantly associated with the RNA expression of many other genes, with 213 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PRB2-associated genes across cancer lineages are LRP5L, EFS, and MYL9. Each is linked with PRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRB2-to-partner and partner-to-PRB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRB2 versus LRP5L in GBM, with a Pearson correlation of -0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB2→partner) and Y-score (partner→PRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LRP5L →	-1.010	-1.218	.001	<.001	3	1
GBM	EFS →	-1.086	-1.010	.005	.004	3	1
GBM	MYL9 →	+1.324	+0.814	.001	.001	3	1
GBM	SLC35A2 →	+0.443	+0.836	.001	.001	3	1
GBM	LYRM1 →	+0.609	+0.913	<.001	.001	3	1
GBM	UBFD1 →	+0.698	+1.103	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 213 associations by consensus.

PRB2 vs LRP5L — GBM

Explore this scatter interactively →