PRB2

Across TCGA patient cohorts, PRB2 mutation is significantly associated with the RNA expression of many other genes, with 2,057 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PRB2-associated genes across cancer lineages are RNU6-629P, FKBP4P7, and SNX3P1Y. Each is linked with PRB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRB2-to-partner and partner-to-PRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-629P grouped by PRB2-low versus PRB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB2→partner) and Y-score (partner→PRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-629P →	+0.187	+3.606	<.001	.002	3	3
BRCA	FKBP4P7 →	+0.033	+3.602	.002	.004	3	2
UCEC	SNX3P1Y →	+0.111	+4.671	<.001	.002	3	2
UCEC	CRYBB2P1 →	+0.593	+3.385	<.001	.004	3	2
SKCM	JOSD1 →	+0.308	+2.095	.007	<.001	3	2
SKCM	PACSIN2 →	+0.414	+2.584	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,057 associations by consensus.

RNU6-629P by PRB2 expression — UCEC

Explore this box plot interactively →