PRB2

Across TCGA cell cohorts, PRB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 904 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PRB2-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Negative regulation of mRNA metabolic process, and Negative regulation of amyloid precursor protein biosynthetic process. Each is linked with PRB2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PRB2-to-partner and partner-to-PRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by PRB2-low versus PRB2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB2→partner) and Y-score (partner→PRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of alternative mRNA splicing, via spliceosome →	+0.075	+0.403	.001	.001	3	6
BLOOD_Leukemia	Negative regulation of mRNA metabolic process →	+0.035	+0.062	<.001	<.001	3	5
LUNG_NSCLC_LUSC	Negative regulation of amyloid precursor protein biosynthetic process →	+0.128	+0.153	.003	.008	3	5
BLOOD_Leukemia	Attachment of mitotic spindle microtubules to kinetochore →	+0.057	+0.087	.004	.005	3	4
OVARY	Negative regulation of gene expression, epigenetic →	+0.040	+0.061	.008	.007	2	5
BLOOD_Lymphoma	Regulation of chromosome organization →	+0.043	+0.106	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 904 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by PRB2 expression — LUNG_SCLC

Explore this box plot interactively →