PRB2

Across TCGA cell cohorts, PRB2 mutation is significantly associated with the mutation status of many other genes, with 439 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRB2-associated genes across cancer lineages are NIPBL, ITSN2, and PTH2R. Each is linked with PRB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRB2-to-partner and partner-to-PRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIPBL grouped by PRB2-low versus PRB2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB2→partner) and Y-score (partner→PRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NIPBL →	+2.362	+2.943	.008	.008	1	3
SKIN	ITSN2 →	+3.117	+3.117	.009	.009	1	3
LUNG_NSCLC_LUAD	PTH2R →	+3.584	+4.063	.003	.003	1	3
LARGE_INTESTINE	SFMBT1 →	+3.087	+4.392	.005	.005	1	3
PANCREAS	CATSPERB →	+5.115	+5.115	.005	.005	1	2
PANCREAS	MYOM1 →	+5.115	+5.115	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 439 associations by consensus.

NIPBL by PRB2 expression — SKIN

Explore this box plot interactively →