PRAMEF8

Across TCGA patient cohorts, PRAMEF8 mutation is significantly associated with the RNA expression of many other genes, with 137 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PRAMEF8-associated genes across cancer lineages are MIR6747, RNA5SP72, and MIR629. Each is linked with PRAMEF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF8-to-partner and partner-to-PRAMEF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6747 grouped by PRAMEF8-low versus PRAMEF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF8→partner) and Y-score (partner→PRAMEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6747 →	+0.890	+3.205	<.001	.003	3	2
UCEC	RNA5SP72 →	+0.500	+4.031	<.001	<.001	3	2
UCEC	MIR629 →	+0.313	+3.997	<.001	.009	3	2
SKCM	MIR6871 →	+0.632	+2.769	<.001	.008	3	2
SKCM	FTH1P27 →	+0.168	+3.918	<.001	<.001	3	1
SKCM	LINC01221 →	+0.088	+3.487	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 137 associations by consensus.

MIR6747 by PRAMEF8 expression — UCEC

Explore this box plot interactively →