PRAMEF8

RNA — tumor vs normal
Tumor vs NormalRNABox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, PRAMEF8 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of PRAMEF8’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PRAMEF8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRAMEF8 is over-expressed in tumor.

LIHC and BRCA are the cancer types where PRAMEF8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRAMEF8 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
LIHCAllAll+0.196.0302view →
BRCAAllII,III,IV+0.007.0352view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

PRAMEF8–LIHC

Tumor-vs-normal expression box plot for PRAMEF8 RNA in LIHC.

Open the LIHC breakdown →

Exploration