PRAMEF6

Across TCGA cell cohorts, PRAMEF6 RNA expression is significantly associated with the mutation status of many other genes, with 105 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRAMEF6-associated genes across cancer lineages are PTPN21, RELB, and BSN. Each is linked with PRAMEF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF6-to-partner and partner-to-PRAMEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPN21 grouped by PRAMEF6-low versus PRAMEF6-high in LUNG_SCLC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF6→partner) and Y-score (partner→PRAMEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PTPN21 →	+5.029	+0.016	.006	<.001	3	2
SKIN	RELB →	+3.920	+0.128	.005	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	BSN →	+4.510	+0.226	.003	<.001	3	2
CNS	ZNF415 →	+5.754	+0.166	.002	<.001	3	2
CNS	ZFPM1 →	+4.754	+0.098	.005	<.001	3	2
OESOPHAGUS	CELSR1 →	+2.857	+0.004	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

PTPN21 by PRAMEF6 expression — LUNG_SCLC

Explore this box plot interactively →