PPP5C

Across TCGA patient cohorts, PPP5C mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP5C-associated genes across cancer lineages are Annexin-1, eEF2, and GAPDH. Each is linked with PPP5C in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP5C-to-partner and partner-to-PPP5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by PPP5C-low versus PPP5C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP5C→partner) and Y-score (partner→PPP5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.593	+3.720	.001	<.001	3	4
UCEC	eEF2 →	+0.433	+2.321	<.001	.001	3	3
UCEC	GAPDH →	+0.491	+3.321	.011	.009	3	3
UCEC	MSH6 →	-0.370	-3.169	.001	.018	3	3
UCEC	eIF4E →	+0.186	+3.472	.014	.002	3	2
UCEC	JNK2 →	+0.258	+2.009	<.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Annexin-1 by PPP5C expression — UCEC

Explore this box plot interactively →