PPP5C

Across TCGA cell cohorts, PPP5C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,566 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPP5C-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, DNA replication-dependent chromatin assembly, and Nucleosome disassembly. Each is linked with PPP5C in more than 17 cancer types. Because this analysis shows association rather than direction, both PPP5C-to-partner and partner-to-PPP5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by PPP5C-low versus PPP5C-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP5C→partner) and Y-score (partner→PPP5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA strand elongation involved in DNA replication →	+0.229	+1.016	<.001	<.001	3	18
BONE	DNA replication-dependent chromatin assembly →	+0.194	+0.961	<.001	<.001	3	18
BONE	Nucleosome disassembly →	+0.204	+0.878	<.001	.001	3	17
BONE	Positive regulation of nuclear cell cycle DNA replication →	+0.179	+1.009	.001	<.001	3	17
BONE	DNA replication checkpoint signaling →	+0.251	+0.875	<.001	<.001	3	16
SOFT_TISSUE	Chromosome condensation →	+0.186	+0.991	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,566 associations by consensus.

DNA strand elongation involved in DNA replication by PPP5C expression — BONE

Explore this box plot interactively →