PPP3CB

Across TCGA patient cohorts, PPP3CB mutation is significantly associated with the RNA expression of many other genes, with 3,002 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP3CB-associated genes across cancer lineages are PITPNC1, GPR3, and PRF1. Each is linked with PPP3CB in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP3CB-to-partner and partner-to-PPP3CB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PITPNC1 grouped by PPP3CB-low versus PPP3CB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CB→partner) and Y-score (partner→PPP3CB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PITPNC1 →	+0.558	+1.938	.001	.001	3	3
COAD	GPR3 →	+0.664	+3.459	.001	.005	3	3
COAD	PRF1 →	+1.475	+3.200	<.001	.009	3	2
UCEC	HOXC9 →	+1.106	+2.970	.001	<.001	3	2
UCEC	HOXC10 →	+1.540	+2.263	<.001	<.001	3	2
UCEC	MAP6D1 →	+0.415	+1.992	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,002 associations by consensus.

PITPNC1 by PPP3CB expression — UCEC

Explore this box plot interactively →