PPP3CB

Across TCGA pan-cancer cohorts, PPP3CB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPP3CB’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PPP3CB RNA is repressed in tumor relative to normal tissue. In most cancer types PPP3CB is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, LIHC, and KICH are the cancer types where PPP3CB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP3CB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.472	<.001	11	view →
LIHC	Female	II,III,IV	+0.875	<.001	9	view →
KICH	Female	All	−1.293	<.001	7	view →
KIRP	Male	All	−0.478	<.001	7	view →
UCEC	All	All	−1.044	<.001	6	view →
KIRC	Male	III,IV	−0.496	<.001	6	view →
BRCA	All	All	−0.339	<.001	6	view →
LUSC	All	All	−0.226	.001	6	view →
CHOL	All	All	+1.603	<.001	5	view →
READ	All	All	−0.788	.004	5	view →
COAD	All	All	−0.348	.004	4	view →
LUAD	All	IV	+0.485	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPP3CB–BLCA

Open the BLCA breakdown →