PPP3CB

Across TCGA pan-cancer cohorts, PPP3CB RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PPP3CB data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PPP3CB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP3CB expression acts as an unfavorable survival marker, although some lineages such as LGG and SKCM show a favorable association.

ACC, LIHC, and LGG are the cancer types where PPP3CB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.239	0.620	<.001	60	view →
LIHC	OS	Median	All	0.714	0.836	<.001	51	view →
LGG	DFS	Median	All	0.810	0.660	<.001	48	view →
SKCM	OS	Quartile	All	0.913	0.824	.001	40	view →
BLCA	OS	Median	II,III,IV	0.357	0.494	.008	40	view →
CESC	DFS	Tertile	III,IV	0.174	0.837	<.001	34	view →
MESO	OS	Median	All	0.414	0.198	.004	32	view →
HNSC	OS	Tertile	All	0.592	0.838	.001	30	view →
KIRC	OS	Quartile	All	0.833	0.742	.008	24	view →
PAAD	DFS	Tertile	II,III,IV	0.531	0.307	.004	18	view →
UVM	DFS	Quartile	III,IV	0.182	0.706	.010	12	view →
LUAD	OS	Tertile	All	0.853	0.734	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PPP3CB–ACC (DFS)

Open the ACC breakdown →