PPP3CB

Across TCGA patient cohorts, PPP3CB mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP3CB-associated genes across cancer lineages are Shc_pY317, FoxM1, and ACC_pS79. Each is linked with PPP3CB in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP3CB-to-partner and partner-to-PPP3CB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by PPP3CB-low versus PPP3CB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CB→partner) and Y-score (partner→PPP3CB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.168	-2.115	.001	.016	3	3
UCEC	FoxM1 →	+0.251	+3.523	.006	<.001	3	2
UCEC	ACC_pS79 →	+0.251	+1.362	.040	.037	3	2
UCEC	GATA6 →	-0.128	-1.992	.019	.003	3	2
UCEC	mTOR →	-0.161	-2.115	.004	.016	3	2
UCEC	Notch1 →	+0.141	+2.817	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Shc_pY317 by PPP3CB expression — UCEC

Explore this box plot interactively →