PPP3CA

Across TCGA patient cohorts, PPP3CA mutation is significantly associated with the RNA expression of many other genes, with 3,822 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP3CA-associated genes across cancer lineages are VN1R90P, IMP3, and RNU6-1245P. Each is linked with PPP3CA in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP3CA-to-partner and partner-to-PPP3CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R90P grouped by PPP3CA-low versus PPP3CA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CA→partner) and Y-score (partner→PPP3CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VN1R90P →	+0.118	+4.690	<.001	<.001	3	3
UCEC	IMP3 →	+0.319	+2.115	<.001	<.001	3	3
STAD	RNU6-1245P →	+0.393	+3.078	.004	.007	3	2
CESC	BNIP3P2 →	+0.056	+5.252	<.001	.002	3	2
CESC	RNU6-677P →	+0.395	+3.914	.006	.007	3	2
CESC	RPL12P22 →	+0.065	+4.984	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,822 associations by consensus.

VN1R90P by PPP3CA expression — LUAD

Explore this box plot interactively →