PPP3CA

Across TCGA pan-cancer cohorts, PPP3CA RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PPP3CA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP3CA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP3CA is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

HNSC, STAD, and BRCA are the cancer types where PPP3CA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP3CA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.870	<.001	11	view →
STAD	Male	II,III,IV	+1.015	<.001	6	view →
BRCA	Female	All	−0.324	<.001	6	view →
KIRC	All	All	+0.318	<.001	5	view →
PAAD	Male	All	+0.825	.003	4	view →
KICH	Male	All	+0.673	.004	4	view →
LIHC	All	II,III,IV	+0.402	.010	4	view →
CHOL	All	All	+1.170	<.001	3	view →
LUAD	Female	III,IV	−0.301	.028	3	view →
PRAD	All	All	+0.973	<.001	2	view →
READ	Female	All	−0.618	.010	2	view →
UCEC	All	All	−0.568	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PPP3CA–HNSC

Open the HNSC breakdown →