PPP3CA

Across TCGA cell cohorts, PPP3CA mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP3CA-associated genes across cancer lineages are SEL1L2, FABP9, and PPP1R2C. Each is linked with PPP3CA in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP3CA-to-partner and partner-to-PPP3CA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by PPP3CA-low versus PPP3CA-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CA→partner) and Y-score (partner→PPP3CA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SEL1L2 →	+0.030	+5.087	<.001	.004	3	1
URINARY_TRACT	FABP9 →	+0.056	+5.087	<.001	.004	3	1
LARGE_INTESTINE	PPP1R2C →	+0.036	+2.925	<.001	.007	3	1
LARGE_INTESTINE	OR14K1 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	NPY2R →	+0.003	+3.217	<.001	.006	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.039	+2.994	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SEL1L2 by PPP3CA expression — URINARY_TRACT

Explore this box plot interactively →