PPP2R3B

Across TCGA patient cohorts, PPP2R3B mutation is significantly associated with the RNA expression of many other genes, with 1,383 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R3B-associated genes across cancer lineages are RNU4-58P, MTND4P32, and GCH1. Each is linked with PPP2R3B in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP2R3B-to-partner and partner-to-PPP2R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by PPP2R3B-low versus PPP2R3B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R3B→partner) and Y-score (partner→PPP2R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU4-58P →	+0.234	+5.149	<.001	.001	3	4
COAD	MTND4P32 →	+0.274	+3.026	.008	.006	3	3
UCEC	GCH1 →	+0.544	+1.970	.002	<.001	3	3
STAD	ETFA →	+0.513	+3.388	.002	.004	3	3
UCEC	GZMA →	+0.852	+1.949	.002	.001	3	3
UCEC	RNU6-2 →	+0.851	+2.149	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,383 associations by consensus.

RNU4-58P by PPP2R3B expression — COAD

Explore this box plot interactively →