PPP2R3B

Across TCGA pan-cancer cohorts, PPP2R3B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PPP2R3B data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PPP2R3B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP2R3B expression acts as an unfavorable survival marker, although some lineages such as UVM and PAAD show a favorable association.

KIRC, UVM, and COAD are the cancer types where PPP2R3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.519	0.706	<.001	145	view →
UVM	OS	Median	II,III,IV	0.809	0.438	<.001	112	view →
COAD	OS	Quartile	III,IV	0.563	0.825	.006	42	view →
LIHC	DFS	Quartile	All	0.433	0.651	<.001	37	view →
PAAD	OS	Median	All	0.526	0.262	.001	28	view →
ACC	DFS	Tertile	All	0.349	0.712	.006	24	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	24	view →
SCLC	OS	Median	II,III,IV	0.716	0.409	.004	24	view →
SKCM	DFS	Quartile	All	0.791	0.656	.004	22	view →
BLCA	OS	Median	II,III,IV	0.527	0.356	.004	19	view →
PRAD	DFS	Median	All	0.834	0.930	<.001	18	view →
PCPG	DFS	Tertile	All	0.753	0.964	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PPP2R3B–KIRC (DFS)

Open the KIRC breakdown →