PPP2R2D

Across TCGA patient cohorts, PPP2R2D mutation is significantly associated with the RNA expression of many other genes, with 1,781 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R2D-associated genes across cancer lineages are RNA5SP91, MIR4652, and COX15. Each is linked with PPP2R2D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R2D-to-partner and partner-to-PPP2R2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP91 grouped by PPP2R2D-low versus PPP2R2D-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R2D→partner) and Y-score (partner→PPP2R2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP91 →	+0.440	+4.245	<.001	.008	3	2
CESC	MIR4652 →	+0.565	+5.103	<.001	.008	3	2
UCEC	COX15 →	+0.430	+2.815	.001	.001	3	2
UCEC	FCGR1A →	+0.586	+2.831	.002	.001	3	2
UCEC	PDSS2 →	+0.560	+2.169	<.001	.003	3	2
UCEC	ELP5 →	+0.502	+3.354	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,781 associations by consensus.

RNA5SP91 by PPP2R2D expression — HNSC

Explore this box plot interactively →