PPP2R2D

Across TCGA pan-cancer cohorts, PPP2R2D RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PPP2R2D data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PPP2R2D RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP2R2D expression acts as an unfavorable survival marker, although some lineages such as LGG and THYM show a favorable association.

ACC, LGG, and HNSC are the cancer types where PPP2R2D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.210	0.741	<.001	55	view →
LGG	DFS	Median	All	0.821	0.650	<.001	54	view →
HNSC	OS	Tertile	III,IV	0.589	0.841	.003	37	view →
THYM	OS	Median	II,III,IV	0.959	0.682	.003	33	view →
COAD	OS	Median	III,IV	0.258	0.722	<.001	32	view →
BLCA	OS	Tertile	All	0.423	0.700	.010	28	view →
SARC	OS	Median	All	0.637	0.885	<.001	13	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	9	view →
LIHC	OS	Quartile	III,IV	0.448	0.807	.019	8	view →
KIRP	DFS	Quartile	All	0.948	0.613	.032	8	view →
GBM	DFS	Median	All	0.370	0.215	.017	6	view →
SCLC	DFS	Quartile	II,III,IV	0.826	0.193	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PPP2R2D–ACC (DFS)

Open the ACC breakdown →