PPP2R2D

Across TCGA pan-cancer cohorts, PPP2R2D RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PPP2R2D’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP2R2D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP2R2D is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where PPP2R2D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R2D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.645	<.001	12	view →
THCA	Male	IV	−0.809	<.001	11	view →
KICH	Female	All	−0.510	<.001	6	view →
COAD	Female	All	+0.392	<.001	6	view →
LIHC	Female	II,III,IV	+0.581	<.001	5	view →
STAD	Male	II,III,IV	+0.685	.002	4	view →
CHOL	All	All	+0.757	.001	3	view →
LUAD	Male	All	+0.270	.004	3	view →
BLCA	Male	IV	+0.410	.009	2	view →
PRAD	All	All	+0.348	<.001	2	view →
KIRC	Male	II,III,IV	−0.224	.009	2	view →
ESCA	All	All	+0.477	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PPP2R2D–HNSC

Open the HNSC breakdown →