PPP2R2D

Across TCGA patient cohorts, PPP2R2D mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R2D-associated genes across cancer lineages are Gab2, Rab25, and C-Raf. Each is linked with PPP2R2D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R2D-to-partner and partner-to-PPP2R2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by PPP2R2D-low versus PPP2R2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R2D→partner) and Y-score (partner→PPP2R2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.421	+2.115	.006	.019	3	2
UCEC	Rab25 →	-0.384	-2.115	.008	.019	3	2
COAD	C-Raf →	+0.188	+3.008	.013	.019	3	2
UCEC	14-3-3_beta →	-0.092	-2.973	.037	.035	3	1
UCEC	EGFR_pY1068 →	-0.287	-2.999	.008	.035	3	1
UCEC	A-Raf_pS299 →	-0.154	-2.321	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Gab2 by PPP2R2D expression — UCEC

Explore this box plot interactively →