PPP2R1B

Across TCGA patient cohorts, PPP2R1B mutation is significantly associated with the RNA expression of many other genes, with 1,726 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R1B-associated genes across cancer lineages are ZNF479, RNU6-650P, and TMEM138. Each is linked with PPP2R1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R1B-to-partner and partner-to-PPP2R1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF479 grouped by PPP2R1B-low versus PPP2R1B-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R1B→partner) and Y-score (partner→PPP2R1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	ZNF479 →	+0.178	+5.189	<.001	.006	3	2
LIHC	RNU6-650P →	+0.248	+4.878	<.001	.005	3	2
UCEC	TMEM138 →	+0.212	+2.595	.008	<.001	3	2
UCEC	LSS →	+0.377	+1.917	.009	.001	3	2
UCEC	PKN3 →	+0.771	+2.595	<.001	<.001	3	2
UCEC	MED27 →	+0.324	+3.785	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,726 associations by consensus.

ZNF479 by PPP2R1B expression — SCLC

Explore this box plot interactively →