PPP2R1B

Across TCGA pan-cancer cohorts, PPP2R1B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PPP2R1B data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PPP2R1B RNA is associated with better overall survival. In most high-consensus cancer types, elevated PPP2R1B expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

KIRC, LGG, and BLCA are the cancer types where PPP2R1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	All	0.761	0.535	<.001	64	view →
LGG	DFS	Median	All	0.781	0.884	<.001	51	view →
BLCA	DFS	Quartile	All	0.127	0.607	<.001	32	view →
MESO	OS	Median	All	0.212	0.686	<.001	27	view →
ACC	DFS	Quartile	All	0.102	0.624	.003	24	view →
SKCM	DFS	Tertile	III,IV	0.504	0.842	.004	22	view →
UCEC	DFS	Median	II,III,IV	0.867	0.780	.018	22	view →
LUAD	OS	Tertile	All	0.615	0.741	.008	18	view →
KICH	DFS	Quartile	II,III,IV	0.172	0.900	.008	16	view →
BRCA	OS	Quartile	IV	0.938	0.408	.004	14	view →
LIHC	OS	Tertile	III,IV	0.471	0.220	.004	12	view →
PAAD	OS	Median	II,III,IV	0.665	0.417	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PPP2R1B–KIRC (OS)

Open the KIRC breakdown →