PPP2R1B

Across TCGA pan-cancer cohorts, PPP2R1B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PPP2R1B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PPP2R1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP2R1B is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

BLCA, HNSC, and THCA are the cancer types where PPP2R1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.730	<.001	11	view →
HNSC	All	III,IV	+0.693	<.001	11	view →
THCA	Male	III,IV	−0.720	<.001	10	view →
LUAD	Male	II,III,IV	+0.914	<.001	7	view →
STAD	All	II,III,IV	+0.637	<.001	7	view →
BRCA	All	III,IV	−1.108	<.001	6	view →
KIRP	Male	All	−0.827	<.001	6	view →
UCEC	All	All	+0.692	<.001	6	view →
KIRC	Male	All	−0.338	<.001	6	view →
LIHC	All	III,IV	+0.636	.004	4	view →
KICH	All	All	−0.498	.004	4	view →
LUSC	Male	All	+0.500	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PPP2R1B–BLCA

Open the BLCA breakdown →