PPP2R1B

Across TCGA patient cohorts, PPP2R1B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R1B-associated genes across cancer lineages are PCNA, eIF4E, and INPP4B. Each is linked with PPP2R1B in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP2R1B-to-partner and partner-to-PPP2R1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PPP2R1B-low versus PPP2R1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R1B→partner) and Y-score (partner→PPP2R1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.222	+2.321	.008	.034	3	3
UCEC	eIF4E →	+0.221	+2.906	.007	.001	3	2
UCEC	INPP4B →	-0.342	-2.584	.007	.010	3	2
UCEC	p27_pT198 →	+0.127	+2.000	.002	.010	3	2
UCEC	Akt_pT308 →	+0.678	+1.584	.006	.036	3	2
UCEC	EGFR_pY1068 →	-0.209	-1.584	.034	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PCNA by PPP2R1B expression — UCEC

Explore this box plot interactively →