PPP2R1B

Across TCGA cell cohorts, PPP2R1B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,967 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP2R1B-associated GO terms across cancer lineages are Meiotic sister chromatid cohesion, centromeric, Centromeric sister chromatid cohesion, and Negative regulation of metaphase/anaphase transition of cell cycle. Each is linked with PPP2R1B in more than 19 cancer types. Because this analysis shows association rather than direction, both PPP2R1B-to-partner and partner-to-PPP2R1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic sister chromatid cohesion, centromeric grouped by PPP2R1B-low versus PPP2R1B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R1B→partner) and Y-score (partner→PPP2R1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Meiotic sister chromatid cohesion, centromeric →	+0.222	+1.338	<.001	<.001	3	20
OESOPHAGUS	Centromeric sister chromatid cohesion →	+0.231	+1.169	<.001	<.001	3	18
BREAST	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.126	+0.912	<.001	<.001	3	17
BREAST	Negative regulation of chromosome separation →	+0.126	+0.912	<.001	<.001	3	17
OESOPHAGUS	Meiotic sister chromatid cohesion →	+0.213	+0.995	<.001	<.001	3	17
BLOOD_Lymphoma	Spindle checkpoint signaling →	+0.123	+1.290	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,967 associations by consensus.

Meiotic sister chromatid cohesion, centromeric by PPP2R1B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →