PPP2R1B

Across TCGA cell cohorts, PPP2R1B mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPP2R1B-associated genes across cancer lineages are DEFB125, OPN1MW3, and HTR1E. Each is linked with PPP2R1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R1B-to-partner and partner-to-PPP2R1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB125 grouped by PPP2R1B-low versus PPP2R1B-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R1B→partner) and Y-score (partner→PPP2R1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DEFB125 →	+0.086	+5.643	<.001	.002	3	1
LUNG_SCLC	OPN1MW3 →	+0.013	+5.643	<.001	.002	3	1
LARGE_INTESTINE	HTR1E →	+0.054	+3.345	<.001	.001	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.217	+3.029	<.001	.003	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRT71 →	+0.013	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

DEFB125 by PPP2R1B expression — LUNG_SCLC

Explore this box plot interactively →