PPP2R1A

Across TCGA patient cohorts, PPP2R1A protein abundance is significantly associated with the RNA expression of many other genes, with 16,696 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PPP2R1A-associated genes across cancer lineages are ELP3, PPP2R2A, and DCTN6. Each is linked with PPP2R1A in more than 7 cancer types. Because this analysis shows association rather than direction, both PPP2R1A-to-partner and partner-to-PPP2R1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP2R1A versus ELP3 in UCEC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R1A→partner) and Y-score (partner→PPP2R1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELP3 →	+1.186	+0.140	<.001	<.001	3	8
COAD	PPP2R2A →	+0.651	+0.172	<.001	<.001	3	7
BRCA	DCTN6 →	+0.702	+0.214	<.001	<.001	3	6
BRCA	PPP2CB →	+0.664	+0.170	<.001	<.001	3	6
BRCA	CCDC25 →	+0.532	+0.146	<.001	<.001	3	6
BRCA	KIF13B →	+0.933	+0.127	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,696 associations by consensus.

PPP2R1A vs ELP3 — UCEC

Explore this scatter interactively →