PPP2R1A

Across TCGA pan-cancer cohorts, PPP2R1A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PPP2R1A data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PPP2R1A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPP2R1A expression acts as an unfavorable survival marker, although some lineages such as SCLC and GBM show a favorable association.

MESO, LIHC, and SKCM are the cancer types where PPP2R1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.421	0.653	.001	78	view →
LIHC	OS	Median	All	0.593	0.775	<.001	72	view →
SKCM	OS	Tertile	All	0.276	0.426	<.001	67	view →
ACC	DFS	Tertile	All	0.296	0.724	<.001	57	view →
LUAD	OS	Median	All	0.614	0.749	<.001	52	view →
LUSC	OS	Median	III,IV	0.416	0.730	<.001	43	view →
SCLC	DFS	Tertile	II,III,IV	0.762	0.328	.004	37	view →
BLCA	DFS	Median	III,IV	0.194	0.357	.007	20	view →
GBM	DFS	Median	All	0.384	0.185	.001	17	view →
KIRC	OS	Median	All	0.698	0.495	.008	12	view →
READ	OS	Tertile	II,III,IV	0.371	0.916	.002	10	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PPP2R1A–MESO (OS)

Open the MESO breakdown →