PPP2R1A

Across TCGA pan-cancer cohorts, PPP2R1A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PPP2R1A’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PPP2R1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP2R1A is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LIHC, KICH, and COAD are the cancer types where PPP2R1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.618	<.001	9	view →
KICH	Male	II,III,IV	−0.909	<.001	9	view →
COAD	Female	All	+0.484	<.001	8	view →
LUSC	Male	All	+0.534	<.001	7	view →
BRCA	All	III,IV	+0.650	<.001	6	view →
HNSC	All	All	+0.249	<.001	6	view →
CHOL	Male	All	+2.333	<.001	5	view →
STAD	Male	II,III,IV	+0.682	.003	5	view →
KIRP	All	II,III,IV	+0.391	.002	5	view →
THCA	All	All	+0.170	.001	5	view →
PAAD	All	All	+0.490	.040	2	view →
LUAD	All	III,IV	+0.344	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PPP2R1A–LIHC

Open the LIHC breakdown →