PPP2R1A

Across TCGA patient cohorts, PPP2R1A mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R1A-associated genes across cancer lineages are Caspase-7-cleavedD198, Heregulin, and NF2. Each is linked with PPP2R1A in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP2R1A-to-partner and partner-to-PPP2R1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PPP2R1A-low versus PPP2R1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R1A→partner) and Y-score (partner→PPP2R1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.360	+1.166	.009	.005	3	3
UCEC	Heregulin →	+0.078	+1.211	.006	<.001	3	2
UCEC	NF2 →	-0.184	-1.678	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.387	-1.198	<.001	<.001	3	2
UCEC	AMPK_alpha →	-0.164	-1.554	<.001	<.001	3	2
UCEC	PR →	-0.137	-0.798	.019	.028	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-7-cleavedD198 by PPP2R1A expression — UCEC

Explore this box plot interactively →