PPP2R1A

Across TCGA cell cohorts, PPP2R1A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,955 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPP2R1A-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Positive regulation of anaphase-promoting complex-dependent catabolic process, and Regulation of aggrephagy. Each is linked with PPP2R1A in more than 10 cancer types. Because this analysis shows association rather than direction, both PPP2R1A-to-partner and partner-to-PPP2R1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by PPP2R1A-low versus PPP2R1A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R1A→partner) and Y-score (partner→PPP2R1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.068	+0.499	.002	.007	3	10
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.096	+0.512	.009	.002	3	10
LIVER	Regulation of aggrephagy →	+0.147	+0.667	.004	<.001	2	11
LUNG_SCLC	Cell division →	+0.054	+0.422	.001	.001	3	10
LARGE_INTESTINE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.099	+0.662	<.001	<.001	3	9
BREAST	Regulation of stem cell population maintenance →	+0.091	+0.739	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,955 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by PPP2R1A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →