PPP1R8

Across TCGA patient cohorts, PPP1R8 protein abundance is significantly associated with the RNA expression of many other genes, with 11,357 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPP1R8-associated genes across cancer lineages are MBTD1, WRAP73, and USP1. Each is linked with PPP1R8 in more than 6 cancer types. Because this analysis shows association rather than direction, both PPP1R8-to-partner and partner-to-PPP1R8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP1R8 versus MBTD1 in HNSC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R8→partner) and Y-score (partner→PPP1R8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MBTD1 →	+0.604	+0.140	<.001	<.001	3	7
UCEC	WRAP73 →	+0.665	+0.185	<.001	<.001	3	7
UCEC	USP1 →	+0.679	+0.198	<.001	<.001	3	7
UCEC	KDM1A →	+0.850	+0.218	<.001	<.001	3	7
UCEC	RCC1 →	+0.991	+0.200	<.001	<.001	3	7
GBM	SP4 →	+0.523	+0.194	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,357 associations by consensus.

PPP1R8 vs MBTD1 — HNSC

Explore this scatter interactively →