PPP1R8

Across TCGA pan-cancer cohorts, PPP1R8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PPP1R8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP1R8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP1R8 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and BLCA are the cancer types where PPP1R8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.622	<.001	12	view →
KICH	Female	II,III,IV	−1.594	<.001	9	view →
BLCA	All	All	+0.451	<.001	9	view →
LIHC	Female	III,IV	+0.879	<.001	8	view →
LUAD	Male	All	+0.403	<.001	7	view →
CHOL	Male	All	+1.560	<.001	5	view →
STAD	Male	II,III,IV	+0.801	<.001	5	view →
LUSC	All	All	+0.430	<.001	5	view →
ESCA	All	All	+0.783	.002	4	view →
COAD	All	All	+0.337	<.001	4	view →
BRCA	All	All	+0.122	.013	4	view →
THCA	All	IV	−0.459	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PPP1R8–HNSC

Open the HNSC breakdown →