PPP1R42

Across TCGA patient cohorts, PPP1R42 mutation is significantly associated with the RNA expression of many other genes, with 427 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R42-associated genes across cancer lineages are MIR4694, RPS7P13, and RAB28P2. Each is linked with PPP1R42 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R42-to-partner and partner-to-PPP1R42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4694 grouped by PPP1R42-low versus PPP1R42-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R42→partner) and Y-score (partner→PPP1R42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4694 →	+0.581	+5.736	<.001	.003	3	3
SKCM	RPS7P13 →	+0.071	+4.037	<.001	.003	3	1
SKCM	RAB28P2 →	+0.141	+4.624	<.001	.005	3	1
SKCM	LINC00407 →	+0.199	+3.403	<.001	.006	3	1
SKCM	RNU7-180P →	+0.278	+4.624	<.001	.005	3	1
SKCM	MIR1270 →	+0.854	+3.243	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 427 associations by consensus.

MIR4694 by PPP1R42 expression — HNSC

Explore this box plot interactively →