PPP1R42

Across TCGA pan-cancer cohorts, PPP1R42 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PPP1R42 data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PPP1R42 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP1R42 expression acts as an unfavorable survival marker, although some lineages such as ACC and BRCA show a favorable association.

ACC, BRCA, and LIHC are the cancer types where PPP1R42 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.640	0.227	.001	46	view →
BRCA	OS	Median	IV	0.718	0.179	.001	44	view →
LIHC	OS	Median	II,III,IV	0.246	0.547	.001	43	view →
READ	OS	Median	III,IV	0.409	0.913	.005	42	view →
KIRP	DFS	Tertile	All	1.000	0.624	.009	31	view →
LGG	DFS	Quartile	All	0.637	0.808	<.001	23	view →
UVM	OS	Tertile	II,III,IV	0.834	0.457	.004	21	view →
PAAD	DFS	Quartile	All	0.595	0.267	.003	20	view →
HNSC	OS	Tertile	All	0.260	0.459	.011	16	view →
SARC	DFS	Median	All	0.683	0.538	.003	15	view →
PRAD	DFS	Tertile	All	0.907	0.951	.020	12	view →
ESCA	OS	Quartile	All	0.502	0.766	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PPP1R42–ACC (DFS)

Open the ACC breakdown →