PPP1R3C

Across TCGA patient cohorts, PPP1R3C mutation is significantly associated with the RNA expression of many other genes, with 645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R3C-associated genes across cancer lineages are ERHP2, RNU6-180P, and H2BU2P. Each is linked with PPP1R3C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3C-to-partner and partner-to-PPP1R3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERHP2 grouped by PPP1R3C-low versus PPP1R3C-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3C→partner) and Y-score (partner→PPP1R3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ERHP2 →	+0.124	+7.930	<.001	.008	3	2
LUAD	RNU6-180P →	+0.466	+7.930	<.001	.008	3	2
UCEC	H2BU2P →	+0.252	+2.157	.004	.007	3	2
UCEC	RNA5SP407 →	+0.253	+2.977	<.001	.009	3	2
UCEC	IGKV1OR2-2 →	+0.166	+2.920	<.001	.003	3	2
UCEC	IGHD6-6 →	+0.760	+3.098	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

ERHP2 by PPP1R3C expression — LUAD

Explore this box plot interactively →