PPP1R3C

Across TCGA pan-cancer cohorts, PPP1R3C RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PPP1R3C data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher PPP1R3C RNA is associated with better overall survival. In most high-consensus cancer types, elevated PPP1R3C expression acts as an unfavorable survival marker, although some lineages such as UVM and LGG show a favorable association.

UVM, LGG, and SKCM are the cancer types where PPP1R3C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.791	0.425	<.001	119	view →
LGG	DFS	Median	All	0.802	0.669	<.001	41	view →
SKCM	DFS	Median	II,III,IV	0.420	0.172	.002	35	view →
UCS	DFS	Median	II,III,IV	0.597	0.280	.007	34	view →
ACC	OS	Quartile	III,IV	0.729	0.264	.005	32	view →
STAD	OS	Tertile	III,IV	0.489	0.715	.009	29	view →
OV	OS	Median	All	0.642	0.737	.003	28	view →
ESCA	OS	Tertile	III,IV	0.626	0.381	.012	15	view →
KIRC	DFS	Tertile	IV	0.678	0.476	.013	14	view →
CESC	DFS	Median	All	0.768	0.874	.011	14	view →
PAAD	OS	Median	All	0.305	0.478	.006	12	view →
CHOL	DFS	Median	II,III,IV	0.142	0.566	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PPP1R3C–UVM (OS)

Open the UVM breakdown →