PPP1R3A

Across TCGA cell cohorts, PPP1R3A mutation is significantly associated with the RNA expression of many other genes, with 251 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP1R3A-associated genes across cancer lineages are KLF18, MEAF6, and XAGE3. Each is linked with PPP1R3A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3A-to-partner and partner-to-PPP1R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF18 grouped by PPP1R3A-low versus PPP1R3A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3A→partner) and Y-score (partner→PPP1R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KLF18 →	+0.016	+4.070	<.001	.003	3	2
LUNG_NSCLC_LUAD	MEAF6 →	+0.576	+3.226	.001	.004	3	2
LUNG_NSCLC_LUAD	XAGE3 →	+0.065	+2.215	<.001	.005	3	2
LUNG_NSCLC_LUAD	THAP2 →	+0.573	+3.240	<.001	.003	3	2
BLOOD_Lymphoma	C10orf71 →	+0.557	+4.025	.004	.001	3	2
BLOOD_Leukemia	SNRNP48 →	+0.789	+3.259	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 251 associations by consensus.

KLF18 by PPP1R3A expression — LUNG_SCLC

Explore this box plot interactively →