PPP1R3A

Across TCGA pan-cancer cohorts, PPP1R3A RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated PPP1R3A data layer compared with 11 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PPP1R3A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R3A expression acts as an unfavorable survival marker, although some lineages such as CESC and GBM show a favorable association.

KIRP, HNSC, and UCS are the cancer types where PPP1R3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.293	0.741	<.001	93	view →
HNSC	OS	Median	III,IV	0.559	0.682	.005	50	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
CESC	DFS	Tertile	All	0.942	0.499	.005	36	view →
LUAD	OS	Tertile	III,IV	0.376	0.700	.012	36	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	27	view →
THCA	OS	Tertile	II,III,IV	0.586	0.903	.010	18	view →
COAD	DFS	Tertile	IV	0.089	0.494	<.001	18	view →
SKCM	OS	Tertile	II,III,IV	0.774	0.851	.011	15	view →
BLCA	OS	Tertile	IV	0.398	0.629	.008	9	view →
GBM	DFS	Tertile	All	0.419	0.214	.010	9	view →
LUSC	DFS	Tertile	III,IV	0.764	0.252	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

PPP1R3A–KIRP (OS)

Open the KIRP breakdown →