PPP1R36

Across TCGA patient cohorts, PPP1R36 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R36-associated genes across cancer lineages are 14-3-3_beta, GATA6, and ACVRL1. Each is linked with PPP1R36 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R36-to-partner and partner-to-PPP1R36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PPP1R36-low versus PPP1R36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R36→partner) and Y-score (partner→PPP1R36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.131	-2.432	.001	.018	3	1
UCEC	GATA6 →	-0.169	-2.215	.010	.010	3	1
UCEC	ACVRL1 →	-0.137	-2.986	.015	.035	3	1
UCEC	JNK2 →	+0.198	+1.807	.016	.027	3	1
UCEC	MEK1 →	+0.381	+2.459	.011	.019	3	1
UCEC	Mre11 →	-0.080	-2.973	.023	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

14-3-3_beta by PPP1R36 expression — UCEC

Explore this box plot interactively →