PPP1R36

Across TCGA pan-cancer cohorts, PPP1R36 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPP1R36’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPP1R36 RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R36 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where PPP1R36 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R36 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.745	<.001	12	view →
KIRP	Male	III,IV	−1.377	<.001	11	view →
THCA	Male	All	−0.532	<.001	11	view →
KICH	Male	All	−1.757	<.001	10	view →
COAD	Female	All	−1.164	<.001	9	view →
LUSC	All	III,IV	−1.026	<.001	8	view →
BRCA	All	All	−0.466	<.001	6	view →
LUAD	Female	All	−0.776	<.001	5	view →
CHOL	Male	All	+1.346	.002	4	view →
LIHC	All	All	+0.275	.001	4	view →
READ	All	II,III,IV	−1.015	.022	2	view →
LUAD	All	IV	+0.725	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPP1R36–KIRC

Open the KIRC breakdown →