PPP1R35

Across TCGA patient cohorts, PPP1R35 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PPP1R35-associated genes across cancer lineages are MIR548Z, OFD1P11Y, and LLPHP1. Each is linked with PPP1R35 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R35-to-partner and partner-to-PPP1R35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548Z grouped by PPP1R35-low versus PPP1R35-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R35→partner) and Y-score (partner→PPP1R35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR548Z →	+0.533	+7.741	<.001	.009	3	1
SKCM	OFD1P11Y →	+0.039	+7.816	<.001	.008	3	1
UCEC	LLPHP1 →	+0.248	+4.551	<.001	.009	3	1
UCEC	OR2AP1 →	+0.102	+4.852	<.001	.006	3	1
UCEC	RNY1P8 →	+1.191	+5.453	<.001	.002	3	1
UCEC	RNU6-152P →	+0.523	+4.621	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MIR548Z by PPP1R35 expression — COAD

Explore this box plot interactively →