PPP1R35

Across TCGA pan-cancer cohorts, PPP1R35 RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of PPP1R35’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPP1R35 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP1R35 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where PPP1R35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.026	<.001	12	view →
COAD	Female	II,III,IV	+1.528	<.001	11	view →
KIRP	Male	II,III,IV	+1.104	<.001	11	view →
BLCA	All	III,IV	+1.027	<.001	11	view →
HNSC	Male	III,IV	+1.571	<.001	10	view →
LIHC	Female	II,III,IV	+1.565	<.001	9	view →
LUAD	Female	III,IV	+1.051	<.001	9	view →
STAD	All	II,III,IV	+1.071	<.001	8	view →
LUSC	Male	II,III,IV	+1.030	<.001	8	view →
BRCA	All	III,IV	+0.821	<.001	6	view →
THCA	Male	All	+0.547	<.001	6	view →
CHOL	Male	All	+2.373	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

PPP1R35–KIRC

Open the KIRC breakdown →