Q-omics provides the consensus-scored MIR548Z profile across patient tissues and cancer cell-line models. MIR548Z expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, MIR548Z is differentially expressed in 1, with the highest sampling consensus in LUSC. Additionally, MIR548Z RNA expression shows 7,212 significant gene co-expression associations, with the highest sampling consensus in HNSC. Together, these results highlight COAD, LUSC, and HNSC as cancer lineages where MIR548Z shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR548Z — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR548Z survival associations across molecular data types. MIR548Z RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR548Z RNA expression–survival associations across cancer types. High MIR548Z expression shows unfavorable associations in COAD, LUAD, UCEC, ACC and SKCM, but favorable associations in LUSC. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for MIR548Z RNA expression.
This table summarizes MIR548Z tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR548Z. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR548Z shows higher tumor expression in LUSC. The LUSC box plot shows higher MIR548Z RNA expression in tumor versus normal tissue (log2 FC = +0.402, t-test p = .002).
This table shows molecular features associated with MIR548Z in patient tissues and cancer cell lines. In patient samples, MIR548Z shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set.
